Current Research: 

GHK-Cu, a copper-binding tripeptide, has garnered attention as a potent biomimetic peptide for skincare and haircare applications. This highly hydrophilic peptide, consisting of glycine, histidine, and lysine, promotes skin healing and rejuvenation. GHK-Cu facilitates skin penetration and acts as a delivery system for copper ions, thereby enhancing their therapeutic effects. Notably, it accelerates the healing process by modulating matrix metalloproteinases' expressions and promoting the synthesis of collagen, elastin, and glycosaminoglycans.

Moreover, it demonstrates compatibility with dermal fibroblasts and increases collagen IV synthesis, especially when combined with hyaluronic acid. However, due to the hydrophilic nature of peptides like GHK-Cu, they face challenges in crossing the skin barrier effectively. Various techniques, such as modifying peptide polarity through acyl moiety addition and encapsulation in delivery systems like liposomes, have been explored to address this. Liposomes, in particular, offer advantages as they are biocompatible, biodegradable, and possess both hydrophilic and hydrophobic properties. Encapsulation of GHK-Cu in liposomes has shown promise in improving peptide permeability and enhancing its therapeutic efficacy.

 Our study focused on utilizing cationic and anionic hydrogenated lecithin-based liposomes as carriers for GHK-Cu tripeptide. We investigated the influence of lipid composition and GHK-Cu concentration on liposome properties and stability. Our findings revealed that anionic liposomes exhibited higher encapsulation efficiency of GHK-Cu compared to cationic liposomes, likely due to additional electrostatic interactions.

Moreover, we observed that anionic liposomes were compatible with GHK-Cu and non-cytotoxic towards skin cells. Additionally, our elastase and tyrosinase inhibition tests indicated the potential of GHK-Cu in reducing elastin degeneration, thereby supporting skin structural integrity. Overall, charged liposomes, particularly anionic ones, hold promise as effective carriers for GHK-Cu and offer potential applications in anti-aging cosmetics, considering their safety and compatibility with biomimetic peptides.

Minimum quantity: 1 gram

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