Current Research:

Nonapeptide-1, or Melanostatine-5, is a synthetic peptide composed of nine amino acids. It functions as a competitive antagonist to ??-melanocyte-stimulating hormone (??-MSH) by binding to melanocortin 1 receptors (MC1R) on melanocytes, thereby inhibiting melanin synthesis. Mechanism of Action By competitively binding to MC1R, Nonapeptide-1 prevents ??-MSH from activating the receptor. This inhibition reduces intracellular cyclic adenosine monophosphate (cAMP) levels, decreasing tyrosinase activity, the key enzyme in melanin production.

 Consequently, melanin synthesis is reduced, resulting in a lighter skin tone and diminished hyperpigmentation. Applications in Skincare Due to its ability to modulate melanin production, Nonapeptide-1 is incorporated into various cosmetic formulations aimed at skin brightening and treating hyperpigmentation disorders such as melasma and age spots. Its targeted action offers a gentler alternative to traditional depigmenting agents, minimizing potential side effects. Safety Profile Nonapeptide-1 has been evaluated for safety in cosmetic applications.

Studies indicate that it is generally well-tolerated when used within recommended concentrations. However, as with any active ingredient, it is advisable to conduct patch testing to ensure individual compatibility. Conclusion Nonapeptide-1 is an effective agent in skin care for reducing hyperpigmentation and promoting a more even skin tone. Its specific mechanism of action allows for targeted treatment, making it a valuable component in cosmetic formulations addressing pigmentation concerns.

Specifications
CAS No.：158563-45-2
Purity：≥98%
Molecular Weight：1206.62 g/mol
Molecular Formula：C61H87N15O9S
Appearance： White powder
Storage Condition：-20 ℃

Size: 1-Gram